Director, Inventory & Cost Accounting

Amylyx has an audacious mission to usher in a new era for treating diseases with high unmet needs. Where others see challenges, we see opportunities that we pursue with urgency, rigorous science, and unwavering commitment to the communities we serve. We are a clinical-stage company currently focused on post-bariatric hypoglycemia (PBH), Wolfram syndrome, and amyotrophic lateral sclerosis (ALS).

Our mission is powered by our people. Our core values – be audacious, be curious, be authentic, be engaged, and be accountable – creating a culture of caring. Amylyx has assembled an experienced team ready to take action because the communities we serve have no time to wait. If you share our passion and are determined to tackle some of medicine’s toughest problems, we encourage you to read the opportunity below and apply.

The Opportunity

As Amylyx prepares for future commercialization, we are building the inventory and cost accounting capabilities needed to support a scalable, compliant, and system-enabled operating model. The Director, Inventory & Cost Accounting will serve as the leader and subject matter expert for inventory & cost accounting, cost of sales, standard costing, inventory valuation, and related U.S. GAAP requirements.

This role will be responsible for leading the buildout of the inventory and cost accounting function, including processes, policies, controls, documentation, reporting, and NetSuite-enabled workflows. The Director will partner closely with Supply Chain, Quality, FP&A, IT, external manufacturing partners, external & internal auditors, and the broader Finance organization to ensure inventory and cost of sales are accurately captured, analyzed, controlled, and reported as Amylyx advances toward commercial launch.

Reporting to the Sr. Director, Corporate Accounting, this position requires a hands-on, systems-oriented accounting leader with deep cost accounting expertise, strong business judgment, and the ability to build scalable practices in a dynamic, evolving environment.

We anticipate hiring the Director, Inventory & Cost Accounting in September 2026.

Responsibilities

• Lead the buildout of Amylyx’s inventory and cost of sales accounting function, including scalable processes, policies, controls, documentation, and close procedures.
• Develop and manage complete and accurate standard costs, partner with FP&A to build cost of sales budgets and forecasts, manage related variance analyses, and ensure inventory and cost of sales are appropriately capitalized and valued in accordance with U.S. GAAP.
• Serve as the company’s subject matter expert for inventory accounting, standard costing, cost of sales, valuation, capitalization, reserves, purchase price and production variances, and related U.S. GAAP matters.
• Own the design, implementation, and optimization of inventory and cost accounting processes in NetSuite, partnering with IT, Finance, Supply Chain, Quality, and external partners.
• Oversee monthly and quarterly...