Scientist I/II: in vivo Pharmacology / Immuno-Oncology

Scientist I/II: in vivo Pharmacology / Immuno-Oncology  At Kernal Bio, we engineer human cells inside the body using selective mRNA-LNP technology to treat cancer and autoimmune diseases. Our AI-designed mRNAs, delivered via antibody-decorated lipid nanoparticles (LNPs), ensure precise targeting and minimize off-target effects. Our KR-402 program focuses on hematological malignancies and autoimmune disorders, achieving >90% in vivo delivery efficiency with T-cell-targeted LNPs. The KR-335 program, targeting solid tumors resistant to standard immunotherapies, shows a 100x therapeutic index with strong efficacy and tolerability in preclinical models, including mice and non-human primates. Based in Boston, MA, and backed by Hummingbird Ventures, Amgen Ventures, and NASA, Kernal Bio is revolutionizing mRNA therapeutics by leveraging AI to deliver precision treatments within the body. Job Summary: We seek an accomplished highly motivated Scientist I/II to contribute to the development of Kernal Bio’s mRNA 2.0 platform for therapeutic applications in Boston, Massachussetts. The successful candidate will join a dynamic team of scientists and play a leading role in pre-clinically characterizing mRNA-LNP drug candidates in in vivo models. Candidate should have experience working with murine models of cancer and/or autoimmune diseases.  Responsibilities:  Provide technical and scientific expertise in in vivo pharmacology to enable target identification, validation, and prioritization. Conduct studies in mice with primary focus on in vivo anti-tumor efficacy, PK/PD relationship, and combination strategy, biomarker identification. Perform standard and complex in vivo procedures including dosing all routes, tumor implant, tumor measurements and tissue necropsy.  Ex vivo analysis of immune cells from tumor and tissues, including collection and processing of multiple samples. Perform routine mammalian cell culture and transfection. Analyze, summarize, interpret, and present experimental results to team members and management. Contribute to technical discussions, publications and intellectual property related to the development and application of Kernal’s proprietary technologies. Participate in experimental design and troubleshooting efforts. Maintain up-to-date electronic laboratory notebook records and communicate results to team members in written technical reports and oral presentations. Explore new technologies and methods to optimize current processes in a fast-paced research environment .  Requirements:  BS/MS in Biology, Pharmacology, Oncology, Immunology or equivalent experience in a related discipline. > 4 years of laboratory work experience in academia or industry. Hands on laboratory skills.  In vivo skills with rodents (IV, IP, IT, SC, PO dosing), blood/tissue collection. Excellent in vivo study organization skills, approaching complex tasks with efficiency. Experience with animal mode...