Senior Director, Toxicology (CNS Specialist)

Description of Role Centessa is seeking a Senior Director, Toxicology to provide scientific and technical leadership for nonclinical safety in our CNS programs. The Senior Director will drive program-level toxicology strategy from target selection and lead optimization through IND-enabling activities, clinical advancement, and NDA submission, with a particular focus on CNS small molecules. The successful candidate will work independently to direct their own program work, provide day-to-day scientific guidance to entry-level toxicology staff, and collaborate closely with peers across nonclinical and development functions. The Senior Director will own design, oversight, and interpretation of toxicology and safety pharmacology studies executed at CROs and will author the toxicology contributions to global regulatory submissions. Key Responsibilities Define and execute nonclinical safety strategies for assigned small molecule CNS programs across discovery, IND-enabling, and clinical development stages. Develop safety strategies for new CNS targets, lead optimization programs, and platform technologies. Proactively identify gaps and emerging risks within assigned programs and implement risk mitigation plans, engaging external experts as appropriate. Maintain a current understanding of scientific literature and regulatory guidance relevant to CNS toxicological assessment, and sustain a professional network of external subject matter experts to inform program strategy. Design, oversee, and interpret GLP, non-GLP, investigative, and in vitro toxicology and safety pharmacology studies, with emphasis on endpoints and models relevant to CNS-active small molecules. Lead outsourcing efforts for the design, monitoring, execution, and reporting of nonclinical toxicology studies, ensuring scientific quality, regulatory compliance, and timely delivery. Manage and monitor outsourced toxicology and safety pharmacology studies at external CROs, interacting effectively with CRO study directors throughout study conduct. Critically review and edit nonclinical study reports and coordinate report finalization with CROs. Integrate complex nonclinical datasets across toxicology, pathology, DMPK, and pharmacology to inform candidate selection and program decisions. Author and critically review the toxicology sections of global regulatory documents, including pre-IND packages, INDs, CTAs, IBs, DSURs, and NDA submissions. Prepare science-based written responses to nonclinical inquiries from health authorities (FDA, EMA, and other global regulators). Collaborate closely with peers in biology, DMPK, pathology, pharmacology, clinical, regulatory, and CMC to ensure toxicology activities and findings are integrated into overall program plans. Provide day-to-day scientific direction and mentorship to entry-level toxicology staff supporting assigned programs. Work independently to plan, prioritize, and deliver on program toxicology objectives. Qualifications PhD in Toxicology, Ph...