(Senior) Director, Translational Medicine and Diagnostics
THE OPPORTUNITY
The unprecedented convergence of multi-modal data, advanced disease modeling, and computational power is revolutionizing drug discovery. insitro is harnessing this moment to redefine how medicines are developed for complex diseases. Our AI/ML-enabled platforms integrate and scale data to rapidly discover novel biological insights, identify new targets and drugs, and redefine complex diseases. To enable this vision, we are seeking a Director (or Senior Director) of Translational Medicine and Diagnostics.
This role is an opportunity to directly improve patients' lives by leading translational medicine across our three therapeutic areas — neurology/neurodegeneration, metabolism/cardiovascular, and ophthalmology — and by making clinical trials more efficient and beneficial for patients and drug developers through AI/ML and innovative translational strategies.
Reporting directly to the Chief Medical Officer, you will lead the translational medicine function at insitro, supporting the development of multiple therapeutics — biologics, oligonucleotides, and small molecules — along with multimodal biomarkers and diagnostics. This position can be onsite (three days per week) or hybrid (~one week per month) in our South San Francisco office, with additional travel to relevant medical and translational science conferences and health authorities.
RESPONSIBILITIES
Translational Strategy & Leadership
- Build the Function: Build and lead insitro's translational medicine function, from IND/CTA through clinical proof-of-concept, across biologics, oligonucleotides, and small molecules
- Lead Key Assets: Serve as translational lead for advanced pre-clinical and initial clinical-stage assets
- Own End-to-End Strategy: Be accountable for translational medicine strategy, GCP adherence, and regulatory-authority interactions, including biospecimen CRO selection and oversight
Biomarker Science & Patient Stratification
- Design Stratification Strategies: D...