Senior Medical Director, Rheumatology

Alumis Inc. is a precision medicines company with the mission to transform the lives of patients with autoimmune diseases. Even with treatment innovations of the last two decades, many patients with immunologic conditions continue to suffer - our goal is to fundamentally change the outcomes for these patients. We are seeking an experienced Senior Medical Director in Clinical Development who will be involved across the full scope of rheumatology and autoimmune clinical drug development activities from discovery research through first in human, POC, and Phase 3 studies. The role will include leadership of one or more studies within the portfolio and will work closely with all members of the cross-functional asset team, to apply full clinical knowledge to successfully advance clinical programs as well as the overall asset strategy. Principal Responsibilities  Serve as the physician lead for LUMUS, a 388-patient Phase 2b clinical trial designed to evaluate the efficacy, safety, and pharmacokinetics of multiple doses of ESK-001 in adult patients with moderately to severely active, autoantibody-positive SLE.  Provide leadership of in-stream data reviews and reconciliation efforts.  Hold authorship of clinical portions of key study documents, such as Protocol Amendments and Regulatory Submissions.  Provide oversight of the LUMUS medical monitor. • Participates in external scientific engagement, including peer-to-peer interactions with MDs.  Broadly represent the interests of Alumis as a leader, supporting corporate initiatives across rheumatology. Coach, manage, inspire, and support team members to achieve goals by leveraging a focused and collaborative mindset.  Maintain the highest levels of integrity and standards for scientific inquiry in drug development.  Primary Goals During the opening months on the job, this Senior Medical Director will be expected to focus on the following objectives:  Earn the full trust and respect of key internal and external stakeholders by establishing a reputation as a strategic and highly productive partner. Provide hands-on leadership, apply knowledge and expertise, and partner seamlessly with the operations team to help make LUMUS thrive. Focus on improving and maintaining study data quality, including cross-referencing of the main efficacy endpoints. Candidate Requirements  MD (or ex-US equivalent) with board certification in Rheumatology.  5+ years of clinical development experience; having a background in lupus clinical trials is desired.  Proven leadership skills, as evidenced by having managed people within a pharmaceutical company or in a clinical/academic environment.  Ability to assess, understand, and communicate continuously expanding medical and scientific information.  Proven professional track record of strategic, organizational, and executional skills to support project planning across multiple activities, with the ability to antici...