Senior Vice President, Preclinical Toxicology

Senior Vice President, Preclinical Toxicology Nurix Therapeutics is a clinical stage biopharmaceutical company focused on the discovery, development, and commercialization of targeted protein degradation medicines, the next frontier in innovative drug design aimed at improving treatment options for patients with cancer and inflammatory diseases. Powered by a fully AI-integrated discovery engine capable of tackling any protein class, and coupled with unparalleled ligase expertise, Nurix’s dedicated team has built a formidable advantage in translating the science of targeted protein degradation into clinical advancements. Nurix aims to establish degrader-based treatments at the forefront of patient care, writing medicine’s next chapter with a new script to outmatch disease. Position The Senior Vice President, Toxicology (Safety Pharmacology) leads Nurix's nonclinical safety function and reports to the Chief Scientific Officer. This role sets toxicology and safety pharmacology strategy across the portfolio, from discovery through clinical development, and represents Toxicology to senior management, the Board, external partners, and regulatory authorities. The SVP operates across three dimensions: leading an internal team and managing the department's CRO relationships, budget, and study portfolio; setting strategic direction for nonclinical safety across programs and the portfolio; and executing with the scientific rigor and credibility to influence program-level decisions and Nurix's broader R&D direction. Responsibilities Set toxicology and safety pharmacology strategy across the discovery, preclinical, and clinical portfolio, and make sure nonclinical safety plans align with the company's development priorities and risk tolerance. Represent Toxicology on the Research & Early Discovery leadership team and be a key contributor to portfolio prioritization, program governance, and related decisions. Lead and develop an internal Toxicology team, including hiring, mentoring, and setting priorities as workload and the portfolio evolve. Direct the design and execution of preclinical pharmacology, pharmacokinetic, mammalian toxicology, and genetic toxicology IND-enabling studies (GLP and non-GLP), ensuring packages meet regulatory filing standards. Manage the Toxicology department budget and resourcing, including decisions about what stays in-house versus what goes to CRO partners. Select and oversee the CRO and external partner network, including contracting, risk management, and quality oversight of outsourced GLP and non-GLP studies. Serve as the senior toxicology representative in interactions with FDA and other health authorities, including IND, CTA, NDA, BLA, and MAA submissions and agency meetings. Communicate toxicology findings and risk assessments clearly to program teams, senior management, and the Board, translating nonclinical safety data into practical implications for decision-making. Provide toxicology and safety input on busine...