VP, Head of Drug Discovery

The Opportunity:  We are seeking an exceptional scientific leader to oversee our integrated Medicinal Chemistry, Computational Chemistry, Cheminformatics, and Drug Metabolism & Pharmacokinetics (DMPK) organizations. This individual will be responsible for driving the discovery and optimization of transformative small molecule therapeutics by building a highly collaborative, data-driven discovery engine that combines deep scientific expertise with modern computational approaches.  The successful candidate will be a recognized leader in small molecule drug discovery with a proven track record of advancing programs from hit identification through IND filing. They will be a key member of research leadership, fostering an environment where all disciplines work as a unified team to rapidly test hypotheses, learn from experimental data, and deliver differentiated medicines.  This role is ideal for a leader who is energized by solving complex scientific problems, embracing emerging technologies, and building high-performing scientific organizations within a fast-paced biotechnology environment.  We believe breakthrough medicines emerge from the seamless integration of human creativity, rigorous experimentation, and advanced computational science. Our discovery strategy combines hypothesis-driven biology, medicinal chemistry, computational chemistry, structural biology, and DMPK to iteratively design, test, and refine molecules based on quantitative experimental evidence. By coupling deep scientific expertise with state-of-the-art computational technologies, we aim to accelerate learning, improve decision quality, and deliver differentiated therapies for patients with serious diseases.  Your Role:   Scientific Leadership  Lead and integrate the Medicinal Chemistry, Computational Chemistry, Cheminformatics, and DMPK organizations to create a highly effective, collaborative drug discovery engine.   Define and execute scientific strategies that enable rapid progression from target validation to development candidate nomination.   Champion hypothesis-driven drug discovery by integrating predictive computational methods and medicinal chemistry.   Ensure that molecular design decisions are informed by a comprehensive understanding of potency, selectivity, physicochemical properties, ADME, safety, developability, and translational considerations.   Drive scientific excellence through rigorous data analysis, critical thinking, and evidence-based decision making.   Ensure efficiency and optimal resource utilization through integration of emerging technologies when appropriate  Organizational Leadership  Build strong partnerships across biology, biomolecular sciences, translational medicine, a...