Director, Clinical Operations

About Jade Biosciences  Jade Biosciences is a clinical-stage biotechnology company focused on developing best-in-class therapies that address critical unmet needs in autoimmune diseases. Jade’s lead candidate, JADE101, targets the cytokine APRIL, and is currently being evaluated in a Phase 1 clinical trial for the treatment of immunoglobulin A nephropathy. Jade’s pipeline also includes JADE201, an afucosylated anti-BAFF-R monoclonal antibody, as well as JADE301, an undisclosed antibody candidate, both currently in preclinical development. Jade was launched based on assets licensed from Paragon Therapeutics, an antibody discovery engine founded by Fairmount. For more information, visit JadeBiosciences.com and follow the Company on LinkedIn. Role Overview  The Director, Clinical Operations will oversee the strategic and operational execution of clinical trials, leading cross-functional teams and collaborating with internal stakeholders and external vendors. This individual will manage trial budgets, vendor selection, and risk mitigation while contributing technical input to key clinical documents. This individual will also mentor staff, foster strong team and cross-functional relationships, and nimbly adapt in our dynamic organization. With proven leadership, financial acumen, and problem-solving skills, this individual will thrive in Jade’s dynamic environment and evolve to support broader corporate initiatives. This is an exciting opportunity to make significant contributions to Jade’s immunology pipeline, leading trials from first in human single site to global (APAC, LATAM, etc.) phase 3, as assigned.   Key Responsibilities  Performs role of Clinical Operations trial lead for assigned trials and leads cross-functional Study Execution Teams  Develops and executes trial operational strategies and partners cross-functionally to drive trial execution forward; provides strategic and technical recommendations to senior leadership  Directs the selection of CROs and other vendors (IxRS, Central Lab, ancillary/tech vendors), directs development of vendor Scopes of Work (SOW), scope changes, budgets, and vendor payments and partners with CROs and other vendors to deliver on study execution  Creates and tracks clinical trial budgets  Directs risk mitigation, escalation, and resolution activities both internally and with sites and vendors  Directs technical and strategic input into the development of clinical documents (protocols, monitoring plans, informed consent forms, investigator brochures, clinical study reports)   Builds relationships with clinical sites, vendors, and key stakeholders and maintains an understanding of the external landscape and ad...