Director, Translational Biology

Vir Biotechnology, Inc. is a clinical-stage biopharmaceutical company focused on powering the immune system to transform lives by discovering and developing medicines for serious infectious diseases and cancer. Its clinical-stage portfolio includes programs for chronic hepatitis delta and multiple PRO-XTEN® dual-masked T-cell engagers across validated targets in solid tumor indications. Vir Biotechnology also has a preclinical portfolio of programs across a range of infectious diseases and oncologic malignancies.  Vir Biotechnology has exclusive rights to the universal PRO-XTEN® masking platform for oncology and infectious disease. PRO-XTEN® is a trademark of Amunix Pharmaceuticals, Inc., a Sanofi company. We believe the success of our colleagues drives the success of our mission. We are committed to creating a company where everyone feels supported and encouraged to give their best. THE OPPORTUNITY Vir Bio is looking for a Director, Translational Biology to drive biomarker strategy across our pipeline, from preclinical discovery through clinical development. Reporting to the VP, Translational Biology, you will translate complex immunologic and molecular insights into actionable plans that inform mechanism of action, dose selection, patient selection, and clinical outcomes in immune-oncology and related disease areas. You will lead biomarker design and execution for key programs, oversee advanced translational assays in both preclinical models and human samples, and partner closely with discovery, clinical, data science, and external collaborators to deliver high-quality biomarker data. You will manage scientists, contribute to regulatory filings, and help build the infrastructure and partnerships needed to advance cutting-edge biomarker science. This role is located in our San Francisco headquarters with an expectation of at least 3 days per week in office. WHAT YOU'LL DO Serve as the biomarker lead for specific programs from preclinical through clinical development Develop and execute biomarker strategies, including design and oversight of preclinical biomarker assessments and contribution to clinical biomarker plans to inform dose selection and development of immune-oncology agents Plan and oversee the validation and execution of human immunologic and molecular methods in preclinical and clinical studies to meet biomarker objectives Support activities related to deliverables and documentation for regulatory submissions (e.g., INDs, BLAs/NDAs) and contribute to authoring INDs, IBs, clinical study protocols, and related documents Manage pilots and method validation with external vendors to ensure robust, fit-for-purpose biomarker assays Collaborate with discovery, clinical, and data science colleagues to refine biomarker hypotheses, design studies, and analyze and interpret key datasets Lead a team, providing scientific guidance and mentorship in immunology and biomarkers while overseeing team performance and development Repres...