Principal Scientist, Clinical Biomarker, Immunology & Immuno-Oncology (Hematology)

Legend Biotech is a global biotechnology company dedicated to treating, and one day curing, life-threatening diseases. Headquartered in Somerset, New Jersey, we are developing advanced cell therapies across a diverse array of technology platforms, including autologous and allogenic chimeric antigen receptor T-cell, T-cell receptor (TCR-T), and natural killer (NK) cell-based immunotherapy. From our three R&D sites around the world, we apply these innovative technologies to pursue the discovery of safe, efficacious and cutting-edge therapeutics for patients worldwide.   Legend Biotech entered into a global collaboration agreement with Janssen, one of the pharmaceutical companies of Johnson & Johnson, to jointly develop and commercialize ciltacabtagene autolecuel (cilta-cel). Our strategic partnership is designed to combine the strengths and expertise of both companies to advance the promise of an immunotherapy in the treatment of multiple myeloma.Legend Biotech is seeking a Principal Scientist, Clinical Biomarker, Immunology & Immuno-Oncology (Hematology) as part of the Early Drug Development team based in Somerset, NJ.   Role Overview We are seeking a highly motivated and innovative Principal Scientist to join our immunology and immuno-oncology (IO) clinical biomarker projects, with a dedicated focus on hematological malignancies. In this role, you will drive the clinical translational understanding of novel therapy in hematology. You will serve as the biology lead on cross-functional project teams, drive MOA of novel cell therapy and clinical biomarker strategy.   Key Responsibilities Scientific Leadership: Design, execute, and analysis results from clinical studies to investigate the mechanisms of action for novel IO targets in hematological indications (e.g., AML, DLBCL, Multiple Myeloma). Translational Strategy: Bridge discovery and clinical development by utilizing primary human samples and clinical datasets to validate targets and understand the immune microenvironment in hematology. Understanding MOA: Oversee the generation and interpretation of high-dimensional molecular and cellular data. Leverage advanced single-cell technologies (e.g., scRNA-seq) to deeply profile immune cell compartments, particularly T-cell states and exhaustion markers, to inform patient stratification and biomarker hypotheses. Cross-Functional Collaboration: Partner closely with other functional teams for better understanding of MOA and fundamental immunology.   Requirements Ph.D. in Immunology, Immuno-Oncology, Cellular Biology, or a closely related discipline, can initiate and lead data driven MOA studies. Experience with cell therapy a plus but not required. A minimum of 5-8+ years of post-doctoral and/or industry experience in biotech or pharma, with a proven track record of advancing IO programs. Deep understanding of immunology, particularly T cell biology highly desirable. Hematology Expertise: Deep biological understanding ...